The rheological behavior of Patches I, II and III was predominantly elastic. Results: Polarized microscopy revealed the absence of aggregates and crystal forms of NTP-HCl in all transdermal patches after 30 days of storage. In order to characterize the chitosan patches, polarized microscopy, in vitro skin permeation studies by passive diffusion and iontophoresis and rheological and bioadhesion studies were performed. Methods: 16 g of each chitosan patch formulation (I, II and III, see ) was poured onto rectangular glass plates (64 cm 2) at a height of 1 mm and dried for 24 h at room temperature. Objective: The aim of this study was to prepare and characterize both physically and biopharmaceutically, a nortriptyline hydrochloride (NTP-HCl) patch formulated in chitosan.
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